The quest for continuous process improvement in the biopharma industry
Congratulations! You successfully developed a new target molecule and brought it to market. Now what? Almost immediately after introducing a new commercial product, the focus shifts to how the developed process can be optimized to increase efficiency, reduce costs, and maximize yield without compromising supply quality.
Embracing innovation and process improvement is essential for staying competitive and achieving better outcomes in the long run. However, once established processes and methods are in place, any changes can be daunting due to associated risks and compliance challenges. So, where do you begin?
Elevate your processes with Biopharma 4.0 innovative technologies
Biopharma 4.0 offers significant potential for enhancing biopharmaceutical manufacturing procedures, elevating product standards, and cutting down expenses. Supported by QbD and PAT frameworks, Biopharma 4.0 integrates the principles of Industry 4.0 digital transformation into the biopharmaceutical manufacturing industry. It aims to establish automated smart factories equipped with real-time surveillance and process control. Implementing Biopharma 4.0 tools like Raman spectroscopy and digital Memosens technology allows for early identification of process discrepancies and predictive maintenance.
Endress+Hauser measurement technologies can be applied to monitor regulatory-approved bioprocesses with no impact to compliance, as long as they are not used as primary process or quality control tools (unless the filing is updated accordingly). This reduces the likelihood of batch failures while ensuring consistent product quality and yield. Strengthening existing processes with new technologies is strongly encouraged by regulatory bodies, benefiting both manufacturers and patients.
Tutorials
Learn about our inline analysis technologies
Curious about the measurement principles behind our inline measurement systems? Check out these pages for some brief tutorials.
Quality & Compliance
What is Raman spectroscopy?
Boost plant safety, ensure product quality, and optimize operations. Raman spectroscopy measures the composition and molecular structure of your samples from lab-to-process in real time.
Make life easier, increase process safety and stay connected with Memosens 2.0 digital technology.
Related topics
Liquiline: cutting-edge transmitter platform
By choosing the Liquiline platform, you’re effectively choosing to spend less money on stock holding, save installation time and gain operational safety!
Get to know our full analytic portfolio for bioprocessing
Endress+Hauser offers a complete suite of bioprocessing measurement instrumentation - including world-class Raman systems (spectrometers, probes, optics, and accessories powered by Kaiser Raman technology) and liquid analysis digital analysis systems (photometers, transmitters, Memosens sensors, Memobase software, and assemblies). These offerings are complemented by calibration devices, solutions, and modelling services with support from Endress+Hauser's vast global service and support network.
Download our eBook to learn how our field-proven inline measurement tools can help optimize your bioprocesses.
Make data-driven decisions based on full process transparency.
Unlocking process improvement opportunities begins with vigilant monitoring and precise control of critical measurement parameters in both your upstream and downstream applications. 24/7 inline process measurement provides valuable insights into bioreactor performance, unveiling a deeper understanding of fundamental process behaviors and cellular functioning. Armed with this level of process transparency, you can fine-tune tolerances and make other data-driven decisions to optimize process conditions and efficiency. Endress+Hauser's comprehensive inline measurement systems – including Raman systems and liquid analysis digital sensors – are ideal tools to implement in your Biopharma 4.0 process improvement program toolset.
Success stories
Real-world customer examples
Check out our upstream and downstream case stories.
Upstream case study - find out how Nicro achieved real-time control of fermentation processes
Learn how Nicro moved from time-consuming sample analysis to real-time monitoring of critical parameters in fermentation processes. The result? Inline process monitoring of metabolites without the need of offline sampling helped improve process control for optimized production and increased yield.
Downstream case study - get a sneak peek how Alvotech is gaining valuable UF/DF process insights
Find out how Alvotech is enhancing its downstream processing for biosimilar production by enabling real-time monitoring of the protein purification process during UF/DF. The result? The company can realize cost savings, faster processing, and more proactive decision making for increased efficiency.
Select products for real-time chemical composition measurement
Having pioneered bioprocess Raman with our Kaiser Raman technology, Endress+Hauser has the largest installed base of Raman units in the field and the most customer application successes. Our comprehensive Raman systems – comprised of powerful Raman spectrometers, sampling probes, and optic accessories— are perfectly designed to meet the stringent demands of bioprocessing applications. These innovations have set the bar high for reliable real-time chemical composition analysis of upstream and downstream bioprocesses from lab to process and from batch to continuous operations. Here are just a few highlighted Raman offerings to jumpstart your process improvement efforts.
Select products for measuring your analytical process parameters
For precise and consistent measured values of key process parameters – such as pH, cell growth, conductivity, dissolved oxygen and more – Endress+Hauser offers a range of photometers, transmitters, digital sensors, and assemblies purposely designed with scalability in mind for use in lab, pilot, and process. Our devices feature Heartbeat Technology with built-in predictive maintenance capabilities. Here are just a few highlighted products to explore.
In the realm of biotechnology, today’s Process Analytical Technology (PAT) and process development scientists are constantly exploring innovative solutions. Their mission? To accelerate product development, ensure seamless scalability from lab to production, and enhance existing processes for higher yield.
Develop a new product quickly
Gain accurate bioprocess insights and instill tight parameter control to boost yield, product quality, and time to market
Our Raman spectroscopic systems are powered by Kaiser Raman technology, enabling non-invasive chemical composition analysis of a material without needing to extract, prepare, or destroy the sample.
Water, beverages, dairy products, chemicals or pharmaceuticals have to be analyzed every day. Choose the device best suited to your process needs from our comprehensive product portfolio.
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